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I've compiled Qt 5.0.0 with msvc2010 because I need opengl with configure string configure -prefix%CD% qtbase -opensource -nomake -nomake examples -nomake demo -opengl desktop -platform win32-msvc2010 Now I can start Qt application from QtCreator only. I've put application in WinDBG it's output below CommandLine: D: work workspace WellReader_0_1-build-Qt_5_0_0_msvc2010_opengl-Release release WellReader_0_1.exe Symbol search path is: *** Invalid *** **************************************************************************** * Symbol loading may be unreliable without a symbol search path. * * Use.symfix to have the debugger choose a symbol path. * * After setting your symbol path, use.reload to refresh symbol locations.